Onset of pancuronium and d-tubocurarine blockade with priming
نویسندگان
چکیده
منابع مشابه
Priming of pancuronium with magnesium.
Magnesium inhibits the release of acetylcholine from the motor nerve terminal and thus potentiates the action of the non-depolarizing neuromuscular blocking drugs. We have examined the possibility that this effect might enhance the speed of onset of non-depolarizing block with pancuronium. Following the administration of pancuronium 100 micrograms kg-1, 95% depression of thumb twitch occurred i...
متن کاملA clinical comparison of pancuronium bromide with D-tubocurarine in adult Nigerian patients.
PA~CU~ONrOM B~OMIDE (Organon NA97) is a steroid compound non-depolarizing neuromuscular blocking agent, 1 synthesized by Hewett and Savage in 1964. Following extensive pharmacological studies in animals, Buckett and Bonta 2 suggested that this agent possessed properties similar to those of d-tubocurarine but with certain differences in side effects. Its potency is claimed to be about five times...
متن کاملComparison of speed of onset of fazadinium, pancuronium, tubocurarine and suxamethonium.
Under light general anaesthesia the speed of onset of action of fazadinium, pancuronium, tubocurarine and suxamethonium has been assessed by measuring the decrease in the twitch height of the adductor pollicis muscle following administration of the drugs. Suxamethonium produced 95% depression of the twitch height significantly faster than any of the other drugs, while the onset of fazadinium wa...
متن کاملFade characteristics and onset times following administration of pancuronium, tubocurarine and a mixture of both agents.
The onset characteristics of pancuronium, tubocurarine and a mixture of these two neuromuscular blocking drugs were studied during the induction of neuromuscular blockade, using a train-of-four pattern of stimulation. Four characteristics of onset were defined: train-of-four fade = a reduction in the height of the fourth twitch greater than a reduction in the height of the first twitch; latent ...
متن کاملPriming and the onset of neuromuscular blockade with alcuronium.
"Priming" with alcuronium has been studied in 72 female patients. Blockade of single twitch responses of the adductor pollicis by alcuronium 0.15, 0.2 or 0.3 mg kg-1 could be accelerated by priming with a suitable priming portion of the total dose. Giving alcuronium 0.04 mg kg-1 30 s after the induction of anaesthesia, followed by the balance 4 min later, resulted in more rapid neuromuscular bl...
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ژورنال
عنوان ژورنال: Canadian Anaesthetists’ Society Journal
سال: 1986
ISSN: 0008-2856,1496-8975
DOI: 10.1007/bf03014262